Confidence Intervals for Proportions and Related Measures of Effect Size Book

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Confidence Intervals for Proportions and Related Measures of Effect Size

By Robert Gordon Newcombe
  • ISBN Code: : 1439812799
  • Publisher : CRC Press
  • Pages : 468
  • Category : Mathematics
  • Reads : 890
  • Book Compatibility : Pdf, ePub, Mobi, Kindle
  • Pdf : confidence-intervals-for-proportions-and-related-measures-of-effect-size.pdf

Book Excerpt :

Confidence Intervals for Proportions and Related Measures of Effect Size illustrates the use of effect size measures and corresponding confidence intervals as more informative alternatives to the most basic and widely used significance tests. The book provides you with a deep understanding of what happens when these statistical methods are applied

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  • Pdf File: biosimilar-clinical-development.pdf

Book Short Summary:

Biosimilars have the potential to change the way we think about, identify, and manage health problems. They are already impacting both clinical research and patient care, and this impact will only grow as our understanding and technologies improve. Written by a team of experienced specialists in clinical development, this book discusses various potential drug development strategies, the design and analysis of pharmacokinetics (PK) studies, and the design and analysis of efficacy studies.

Emerging Non-Clinical Biostatistics in Biopharmaceutical Development and Manufacturing

By Harry Yang
  • File : Pdf, ePub, Mobi, Kindle
  • Publisher : CRC Press
  • Book Code : 1498704166
  • Total of Pages : 386
  • Category : Mathematics
  • Members : 410
  • Pdf File: emerging-non-clinical-biostatistics-in-biopharmaceutical-development-and-manufacturing.pdf

Book Short Summary:

The premise of Quality by Design (QbD) is that the quality of the pharmaceutical product should be based upon a thorough understanding of both the product and the manufacturing process. This state-of-the-art book provides a single source of information on emerging statistical approaches to QbD and risk-based pharmaceutical development. A comprehensive resource, it combines in-depth explanations of advanced statistical methods with real-life case studies that illustrate practical applications of these methods in QbD implementation.

Applied Biclustering Methods for Big and High-Dimensional Data Using R

By Adetayo Kasim,Ziv Shkedy,Sebastian Kaiser,Sepp Hochreiter,Willem Talloen
  • File : Pdf, ePub, Mobi, Kindle
  • Publisher : CRC Press
  • Book Code : 1482208245
  • Total of Pages : 407
  • Category : Mathematics
  • Members : 134
  • Pdf File: applied-biclustering-methods-for-big-and-high-dimensional-data-using-r.pdf

Book Short Summary:

Proven Methods for Big Data Analysis As big data has become standard in many application areas, challenges have arisen related to methodology and software development, including how to discover meaningful patterns in the vast amounts of data. Addressing these problems, Applied Biclustering Methods for Big and High-Dimensional Data Using R shows how to apply biclustering methods to find local patterns in a big data matrix. The book presents an overview of data analysis using biclustering methods from a practical point of view. Real case studies in drug discovery, genetics, marketing research, biology, toxicity, and sports illustrate the use of several biclustering methods. References to technical details of the methods are provided for readers who wish to investigate the full theoretical background. All the methods are accompanied with R examples that show how to conduct the analyses. The examples, software, and other materials are available on a supplementary website.

Veterinary Epidemiology

By Michael Thrusfield
  • File : Pdf, ePub, Mobi, Kindle
  • Publisher : John Wiley & Sons
  • Book Code : 1118280261
  • Total of Pages : 888
  • Category : Medical
  • Members : 760
  • Pdf File: veterinary-epidemiology.pdf

Book Short Summary:

A comprehensive introduction to the role of epidemiology in veterinary medicine This fully revised and expanded edition of Veterinary Epidemiology introduces readers to the field of veterinary epidemiology. The new edition also adds new chapters on the design of observational studies, validity in epidemiological studies, systematic reviews, and statistical modelling, to deliver more advanced material. This updated edition begins by offering an historical perspective on the development of veterinary medicine. It then addresses the full scope of epidemiology, with chapters covering causality, disease occurrence, determinants, disease patterns, disease ecology, and much more. Veterinary Epidemiology, Fourth Edition: ● Features updates of all chapters to provide a current resource on the subject of veterinary epidemiology ● Presents new chapters essential to the continued advancement of the field ● Includes examples from companion animal, livestock, and avian medicine, as well as aquatic animal diseases ● Focuses on the principles and concepts of epidemiology, surveillance, and diagnostic-test validation and performance ● Includes access to a companion website providing multiple choice questions Veterinary Epidemiology is an invaluable reference for veterinary general practitioners, government veterinarians, agricultural economists, and members of other disciplines interested in animal disease. It is also essential reading for epidemiology students at both the undergraduate and postgraduate levels.

Data and Safety Monitoring Committees in Clinical Trials

By Jay Herson
  • File : Pdf, ePub, Mobi, Kindle
  • Publisher : CRC Press
  • Book Code : 1498784127
  • Total of Pages : 241
  • Category : Mathematics
  • Members : 963
  • Pdf File: data-and-safety-monitoring-committees-in-clinical-trials.pdf

Book Short Summary:

Praise for the first edition: "Given the author’s years of experience as a statistician and as a founder of the first DMC in pharmaceutical industry trials, I highly recommend this book—not only for experts because of its cogent and organized presentation, but more importantly for young investigators who are seeking information about the logistical and philosophical aspects of a DMC." -S. T. Ounpraseuth, The American Statistician In the first edition of this well-regarded book, the author provided a groundbreaking and definitive guide to best practices in pharmaceutical industry data monitoring committees (DMCs). Maintaining all the material from the first edition and adding substantial new material, Data and Safety Monitoring Committees in Clinical Trials, Second Edition is ideal for training professionals to serve on their first DMC as well as for experienced clinical and biostatistical DMC members, sponsor and regulatory agency staff. The second edition guides the reader through newly emerging DMC responsibilities brought about by regulations emphasizing risk vs benefit and the emergence of risk-based monitoring. It also provides the reader with many new statistical methods, clinical trial designs and clinical terminology that have emerged since the first edition. The references have been updated and the very popular end-of-chapter Q&A section has been supplemented with many new experiences since the first edition. New to the Second Edition: Presents statistical methods, tables, listings and graphs appropriate for safety review, efficacy analysis and risk vs benefit analysis, SPERT and PRISMA initiatives. Newly added interim analysis for efficacy and futility section. DMC responsibilities in SUSARs (Serious Unexpected Serious Adverse Reactions), basket trials, umbrella trials, dynamic treatment strategies /SMART trials, pragmatic trials, biosimilar trials, companion diagnostics, etc. DMC responsibilities for data quality and fraud detection (Fraud Recovery Plan) Use of patient reported outcomes of safety Use of meta analysis and data outside the trial New ideas for training and compensation of DMC members Jay Herson is Senior Associate, Biostatistics, Johns Hopkins Bloomberg School of Public Health where he teaches courses on clinical trials and drug development based on his many years experience in clinical trials in academia and the pharmaceutical industry.